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Inaugural Visiting Professorship in Arkansas
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Former SUFU Presidents Winters and Rovner still at work, serving up beverages at the 2016 Annual SUFU Research Foundation Resident Preceptorship! A fun time was had by all at the Park Grill in Millennium Park in Chicago.
Announcing the SUFU Visiting Professorship
This 1-day visiting professorship will be offered to interested training programs and will consist of a lecture series from a member of the SUFU Executive Committee encompassing all aspects of FPMRS, Urodynamics, and Neurourology.
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AUA Office of Research | Research Scholar Award Competition Now Open
The AUA Office of Research is excited to announce that the 2018 Research Scholar Award competition is now open!...
SUNA Core Curriculum for Urologic Nursing
The first edition of the SUNA Core Curriculum for Urologic Nursing is now available. This comprehensive publication is an excellent resource for all urologic nurses....
ICS-SUFU Early Career promotion
ICS now offers a special reduced rate for SUFU early career professionals. For just £40 you can become an ICS early career professional member! ...
2017 Early-Career Investigators Workshop (ECIW) | Now Accepting Nominations
Nominations are now being accepted for the 2017 Early-Career Investigators Workshop! The deadline to submit nominations is Friday, March 31, 2017. ...
Neurourology and Urodynamics
TAC‐302 promotes neurite outgrowth of isolated peripheral neurons and prevents bladder denervation related bladder dysfunctions following bladder outlet obstruction in rats
Wednesday, July 26, 2017
Aims To evaluate the ability of TAC‐302, a cyclohexenoic fatty alcohol derivative, to enhance neurite outgrowth in cultured rat dorsal root ganglion (DRG) neurons, and the preventive effects of TAC‐302 on bladder denervation‐related storage and voiding dysfunctions in rats with bladder outlet obstruction (BOO). Methods Rat DRG neurons were cultured in the presence of TAC‐302. Cell numbers and neurite lengths were quantified after a 24 h culture. BOO was achieved by partial ligature of the proximal urethra in female rats. BOO rats were divided into three groups and orally treated with vehicle of 3 or 30 mg/kg TAC‐302 twice a day for 4 weeks. Cystometry was performed under conscious conditions. Immunohistochemical staining using anti‐PGP9.5 of the bladder muscle layer was performed, and the innervation area was scored. Results TAC‐302 significantly and dose‐dependently increased neurite outgrowth in cultured DRG neurons. BOO rats showed a decreased innervation area in the urinary bladder compared to sham‐operated rats. BOO‐induced denervation of the urinary bladder was partially prevented by oral treatment with TAC‐302. TAC‐302 significantly reduced the frequency of non‐voiding contraction (NVC) and residual urine volume (RUV) compared with the BOO vehicle group (P < 0.05). The innervation area score exhibited significant negative correlations with NVC and RUV, indicating that they increased according to the progression of denervation. Conclusions Our data indicate that TAC‐302 promotes neurite outgrowth in vitro. In addition, TAC‐302 prevents BOO‐induced bladder dysfunction in rats, and has a protective effect on bladder denervation.
Effects of vesical and perfusion pressure on perfusate flow, and flow on vesical pressure, in the isolated perfused working pig bladder reveal a potential mechanism for the re...
Wednesday, July 26, 2017
Aims Although there is evidence that deficits in bladder blood flow negatively impact bladder function, the effects of vesical, and perfusion pressures on bladder perfusion (perfusate flow), and of perfusate flow on vesical pressure, remain poorly understood. The present study used the isolated perfused working pig bladder model to examine the relationships between blood flow, and vesical and perfusion pressures. Methods Vesical arteries of pig bladders obtained from a local slaughterhouse were cannulated and perfused with Krebs‐Henseleit solution at different pressures, and with carbachol to cause bladder contraction. The urethra of each bladder was cannulated to permit filling (10 mL/min), isovolumetric contraction and emptying. A ureter was cannulated with a pressure sensor to monitor vesical pressure. Results When at rest (50 mL vesical volume), bladder vesical pressure was 8.06 ± 1.5 mmHg and perfusate flow driven by a pressure gradient of 105 mmHg was 22.5 ± 2 mL/min (58.9 ± 7.8 mL/min‐100 g). During filling, vesical pressure increased and flow decreased, but not necessarily in‐parallel. Perfusate flow decreased transiently during isovolumetric contraction, and flow increased during emptying. A reduction in perfusion pressure from ∼105 to ∼40 mmHg reduced flow from ∼70 to ∼20 mL/min‐100g, and reduced flow correlated with reduced vesical pressure. Conclusion Perfusate flow is dependent on bladder perfusion pressure, and not necessarily reciprocally dependent on vesical pressure. Vesical pressure is highly sensitive to the level of perfusate flow, which supports the hypothesis that vesical pressure is dependent on the level of detrusor smooth muscle contractile activity (tone), and that compliance is dependent on bladder perfusion.
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